Assay Detail
Binding
CHEMBL872697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards sigma opioid receptor was determined in rat cerebral homogenate using [3H]haloperidol as radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Identification and exploitation of the sigma-opiate pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.50 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12047 | — | — | 1 | 8.41 |
| CHEMBL20804 | — | — | 1 | 8.32 |
| CHEMBL20626 | — | — | 1 | 7.85 |
| CHEMBL20302 | — | — | 1 | 7.80 |
| CHEMBL1907648 | — | — | 1 | 7.50 |
| CHEMBL278585 | — | — | 1 | 7.34 |
| CHEMBL1907647 | — | — | 1 | 7.14 |
| CHEMBL1907644 | N-BENZYLAMPHETAMINE | — | 1 | 6.99 |
| CHEMBL1907645 | — | — | 1 | 6.18 |
| CHEMBL405 | AMPHETAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12047 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL20804 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL20626 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL20302 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1907648 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL278585 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1907647 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL1907644 | N-BENZYLAMPHETAMINE | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL1907645 | — | Ki | = | 664.0 | nM | 6.18 |
| CHEMBL405 | AMPHETAMINE | Ki | > | 50000.0 | nM | - |