Assay Detail
Binding
CHEMBL805753
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for affinity towards sigma-3 receptor
36
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.45 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317029 | — | — | 2 | 9.54 |
| CHEMBL104945 | — | — | 3 | 9.28 |
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 9.00 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 9.00 |
| CHEMBL54661 | Z-FLUPENTIXOL | — | 1 | 8.65 |
| CHEMBL323287 | — | — | 1 | 8.65 |
| CHEMBL134109 | — | — | 1 | 8.35 |
| CHEMBL320190 | — | — | 1 | 8.26 |
| CHEMBL105645 | — | — | 2 | 8.21 |
| CHEMBL87321 | — | — | 1 | 7.98 |
| CHEMBL134215 | — | — | 1 | 7.89 |
| CHEMBL42055 | E-FLUPENTIXOL | 2.0 | 1 | 7.83 |
| CHEMBL104622 | — | — | 2 | 7.76 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.44 |
| CHEMBL1255588 | — | — | 1 | 7.28 |
| CHEMBL133847 | — | — | 1 | 7.23 |
| CHEMBL104444 | — | — | 1 | 7.10 |
| CHEMBL18786 | CINANSERIN | 2.0 | 1 | 6.74 |
| CHEMBL60859 | BMY-14802 | — | 1 | 6.67 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.67 |
| CHEMBL781 | MAZINDOL | 4.0 | 1 | 6.63 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.41 |
| CHEMBL129768 | — | — | 1 | 6.36 |
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 6.26 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 6.23 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 6.07 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 1 | 6.04 |
| CHEMBL320435 | — | — | 2 | 6.02 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 6.02 |
| CHEMBL282567 | PROADIFEN | 2.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317029 | — | IC50 | = | 0.2884 | nM | 9.54 |
| CHEMBL104945 | — | IC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL317029 | — | IC50 | = | 0.7079 | nM | 9.15 |
| CHEMBL281594 | VANOXERINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL51 | KETANSERIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL104945 | — | IC50 | = | 1.738 | nM | 8.76 |
| CHEMBL54661 | Z-FLUPENTIXOL | IC50 | = | 2.239 | nM | 8.65 |
| CHEMBL323287 | — | IC50 | = | 2.239 | nM | 8.65 |
| CHEMBL104945 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL134109 | — | IC50 | = | 4.467 | nM | 8.35 |
| CHEMBL320190 | — | IC50 | = | 5.495 | nM | 8.26 |
| CHEMBL105645 | — | IC50 | = | 6.166 | nM | 8.21 |
| CHEMBL87321 | — | IC50 | = | 10.47 | nM | 7.98 |
| CHEMBL134215 | — | IC50 | = | 12.88 | nM | 7.89 |
| CHEMBL42055 | E-FLUPENTIXOL | IC50 | = | 14.79 | nM | 7.83 |
| CHEMBL105645 | — | IC50 | = | 16.98 | nM | 7.77 |
| CHEMBL104622 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL1255588 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL133847 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL104444 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL104622 | — | IC50 | = | 85.11 | nM | 7.07 |
| CHEMBL18786 | CINANSERIN | IC50 | = | 181.97 | nM | 6.74 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL781 | MAZINDOL | IC50 | = | 234.42 | nM | 6.63 |
| CHEMBL62 | SCH-23390 | IC50 | = | 389.05 | nM | 6.41 |
| CHEMBL129768 | — | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL597 | PHENTOLAMINE | IC50 | = | 549.54 | nM | 6.26 |
| CHEMBL275707 | RIMCAZOLE | IC50 | = | 588.84 | nM | 6.23 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL1065 | METHYSERGIDE | IC50 | = | 912.01 | nM | 6.04 |
| CHEMBL320435 | — | IC50 | = | 954.99 | nM | 6.02 |
| CHEMBL267930 | SPIPERONE | IC50 | = | 954.99 | nM | 6.02 |
| CHEMBL320435 | — | IC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL282567 | PROADIFEN | IC50 | = | 1584.89 | nM | 5.80 |