Assay Detail
Functional
CHEMBL808707
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Inhibition of Trypanosoma rhodesiense (strain STIB900) was determined using blood stream from trypomastigotes
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.95 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434024 | — | — | 1 | 6.66 |
| CHEMBL55140 | — | — | 1 | 6.16 |
| CHEMBL293522 | — | — | 1 | 5.77 |
| CHEMBL55812 | OLPADRONIC ACID | 2.0 | 1 | 5.27 |
| CHEMBL55358 | — | — | 1 | 5.11 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 5.07 |
| CHEMBL301247 | — | — | 1 | 5.07 |
| CHEMBL55359 | — | — | 1 | 4.70 |
| CHEMBL56556 | — | — | 1 | 4.67 |
| CHEMBL301471 | — | — | 1 | 4.55 |
| CHEMBL55214 | NERIDRONIC ACID | 3.0 | 1 | 4.50 |
| CHEMBL417932 | — | — | 1 | 4.40 |
| CHEMBL299988 | — | — | 1 | 4.21 |
| CHEMBL52761 | — | — | 1 | 4.04 |
| CHEMBL299491 | — | — | 1 | 4.00 |
| CHEMBL55886 | — | — | 1 | - |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | - |
| CHEMBL298771 | — | — | 1 | - |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434024 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL55140 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL293522 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL55812 | OLPADRONIC ACID | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL55358 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL301247 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL55359 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL56556 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL301471 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL55214 | NERIDRONIC ACID | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL417932 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL299988 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL52761 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL299491 | — | IC50 | = | 99800.0 | nM | 4.00 |
| CHEMBL55886 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 177000.0 | nM | - |
| CHEMBL298771 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL870 | ALENDRONIC ACID | IC50 | > | 200000.0 | nM | - |