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Assay Detail

CHEMBL812093

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Functional
In vitro antiparasitic activity against Trypanosoma cruzi (amastigotes)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi.
Szajnman SH, Bailey BN, Docampo R, Rodriguez JB.
Bioorg Med Chem Lett (2001) 11 : 789 -792
PubMed 11277521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.40 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39581 1 4.80
CHEMBL55264 1 4.74
CHEMBL52761 1 4.67
CHEMBL55810 1 4.27
CHEMBL870 ALENDRONIC ACID 4.0 1 4.19
CHEMBL834 PAMIDRONIC ACID 4.0 1 4.19
CHEMBL110971 1 4.18
CHEMBL299988 1 4.16
CHEMBL352266 1 -
CHEMBL54004 1 -
CHEMBL164344 1 -
CHEMBL298547 1 -
CHEMBL923 RISEDRONIC ACID 4.0 1 -
CHEMBL163716 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39581 IC50 = 16000.0 nM 4.80
CHEMBL55264 IC50 = 18100.0 nM 4.74
CHEMBL52761 IC50 = 21400.0 nM 4.67
CHEMBL55810 IC50 = 53500.0 nM 4.27
CHEMBL870 ALENDRONIC ACID IC50 = 65000.0 nM 4.19
CHEMBL834 PAMIDRONIC ACID IC50 = 65000.0 nM 4.19
CHEMBL110971 IC50 = 65800.0 nM 4.18
CHEMBL299988 IC50 = 70000.0 nM 4.16
CHEMBL352266 IC50 > 70000.0 nM -
CHEMBL54004 IC50 > 70000.0 nM -
CHEMBL164344 IC50 > 50000.0 nM -
CHEMBL298547 IC50 > 70000.0 nM -
CHEMBL923 RISEDRONIC ACID IC50 = 300000.0 nM -
CHEMBL163716 IC50 > 50000.0 nM -