Assay Detail
Functional
CHEMBL812099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for antitrypanosomal activity against Trypanosoma cruzi epimastigote, Ystrain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Growth inhibitory effect of naphthofuran and naphthofuranquinone derivatives on Trypanosoma cruzi epimastigotes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.61 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291054 | — | — | 1 | 6.31 |
| CHEMBL36802 | — | — | 1 | 5.72 |
| CHEMBL289256 | — | — | 1 | 5.55 |
| CHEMBL38066 | — | — | 1 | 5.52 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.48 |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291054 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL36802 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL289256 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL38066 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL290960 | NIFURTIMOX | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL110 | BENZNIDAZOLE | IC50 | = | 8050.0 | nM | 5.09 |