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Assay Detail

CHEMBL815775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
log1/Ki value was calculated against Trypsin
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Serine protease 1 (CHEMBL3769)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses.
Yang H, Henkin J, Kim KH, Greer J.
J Med Chem (1990) 33 : 2956 -2961
PubMed 2231595 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 4.20 4.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43961 1 4.20
CHEMBL41853 1 -
CHEMBL1160767 1 -
CHEMBL14047 PHENYLGUANIDINE 1 -
CHEMBL44236 1 -
CHEMBL1160765 1 -
CHEMBL609702 1 -
CHEMBL609703 1 -
CHEMBL404605 1 -
CHEMBL1160763 1 -
CHEMBL1160764 1 -
CHEMBL297076 1 -
CHEMBL20767 4-GUANIDINO-BENZOIC ACID 1 -
CHEMBL1160766 1 -
CHEMBL1160768 1 -
CHEMBL13823 1 -
CHEMBL43415 1 -
CHEMBL41040 1 -
CHEMBL1160769 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43961 Ki = 63095.73 nM 4.20
CHEMBL41853 Ki = 897428.79 nM -
CHEMBL1160767 Ki = 4920395.36 nM -
CHEMBL14047 PHENYLGUANIDINE Ki = 162929.6 nM -
CHEMBL44236 Ki = 10690548.79 nM -
CHEMBL1160765 Ki = 651628.39 nM -
CHEMBL609702 Ki = 352370.87 nM -
CHEMBL609703 Ki = 133045.44 nM -
CHEMBL404605 Ki = 5767664.63 nM -
CHEMBL1160763 Ki = 2779713.27 nM -
CHEMBL1160764 Ki = 881048.87 nM -
CHEMBL297076 Ki = 5888436.55 nM -
CHEMBL20767 4-GUANIDINO-BENZOIC ACID Ki = 10000000.0 nM -
CHEMBL1160766 Ki = 807235.03 nM -
CHEMBL1160768 Ki = 1180320.64 nM -
CHEMBL13823 Ki = 1099005.84 nM -
CHEMBL43415 Ki = 317687.41 nM -
CHEMBL41040 Ki = 119949.93 nM -
CHEMBL1160769 Ki = 3548133.89 nM -