Assay Detail
Binding
CHEMBL817325
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The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Importance of the aromatic residue at position 6 of [Nle(10)]neurokinin A(4-10) for binding to the NK-2 receptor and receptor activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.35 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217406 | NEUROKININ A | — | 1 | 9.15 |
| CHEMBL431641 | — | — | 1 | 7.90 |
| CHEMBL437797 | NEUROKININ B | — | 1 | 7.38 |
| CHEMBL103634 | — | — | 1 | 7.36 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 6.99 |
| CHEMBL103939 | — | — | 1 | 6.81 |
| CHEMBL102128 | — | — | 1 | 5.85 |
| CHEMBL319256 | — | — | 1 | - |
| CHEMBL430650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217406 | NEUROKININ A | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL431641 | — | Ki | = | 12.7 | nM | 7.90 |
| CHEMBL437797 | NEUROKININ B | Ki | = | 42.2 | nM | 7.38 |
| CHEMBL103634 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL235363 | SUBSTANCE P | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL103939 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL102128 | — | Ki | = | 1422.0 | nM | 5.85 |
| CHEMBL319256 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL430650 | — | Ki | > | 2000.0 | nM | - |