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Assay Detail

CHEMBL818672

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of [3H]anandamide transport(ANT) in human lymphoma U937 cell
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-937
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
López-Rodríguez ML, Viso A, Ortega-Gutiérrez S, Fowler CJ, Tiger G, de Lago E, Fernández-Ruiz J, Ramos JA.
J Med Chem (2003) 46 : 1512 -1522
PubMed 12672252 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.10 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL434778 1 6.10
CHEMBL36998 1 5.89
CHEMBL284300 1 5.52
CHEMBL39335 1 5.48
CHEMBL39878 1 5.40
CHEMBL417158 1 5.30
CHEMBL37297 1 5.30
CHEMBL39460 1 5.30
CHEMBL431128 1 5.24
CHEMBL40065 1 5.05
CHEMBL36708 1 4.92
CHEMBL39399 1 4.89
CHEMBL290716 1 4.85
CHEMBL291021 1 4.80
CHEMBL285061 1 4.72
CHEMBL286465 1 4.68
CHEMBL38282 1 4.68
CHEMBL37089 1 4.66
CHEMBL38293 1 4.62
CHEMBL288003 1 4.58
CHEMBL36774 1 -
CHEMBL41226 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL434778 IC50 = 800.0 nM 6.10
CHEMBL36998 IC50 = 1300.0 nM 5.89
CHEMBL284300 IC50 = 3000.0 nM 5.52
CHEMBL39335 IC50 = 3300.0 nM 5.48
CHEMBL39878 IC50 = 4000.0 nM 5.40
CHEMBL417158 IC50 = 5000.0 nM 5.30
CHEMBL37297 IC50 = 5000.0 nM 5.30
CHEMBL39460 IC50 = 5000.0 nM 5.30
CHEMBL431128 IC50 = 5700.0 nM 5.24
CHEMBL40065 IC50 = 9000.0 nM 5.05
CHEMBL36708 IC50 = 12000.0 nM 4.92
CHEMBL39399 IC50 = 12800.0 nM 4.89
CHEMBL290716 IC50 = 14000.0 nM 4.85
CHEMBL291021 IC50 = 16000.0 nM 4.80
CHEMBL285061 IC50 = 19000.0 nM 4.72
CHEMBL286465 IC50 = 21000.0 nM 4.68
CHEMBL38282 IC50 = 21000.0 nM 4.68
CHEMBL37089 IC50 = 22000.0 nM 4.66
CHEMBL38293 IC50 = 24000.0 nM 4.62
CHEMBL288003 IC50 = 26000.0 nM 4.58
CHEMBL36774 IC50 = - nM -
CHEMBL41226 IC50 = 111000.0 nM -