Assay Detail
Binding
CHEMBL820178
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Binding affinity at Vasopressin V1a receptor, performed using [3H]AVP on rat liver
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 5-(4-biphenyl)-3-methyl-4-phenyl-1,2,4-triazole derivatives as a novel class of selective antagonists for the human vasopressin V(1A) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.97 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307483 | — | — | 1 | 9.80 |
| CHEMBL419667 | RELCOVAPTAN | 2.0 | 1 | 8.85 |
| CHEMBL86949 | — | — | 1 | 8.01 |
| CHEMBL89552 | — | — | 1 | 7.76 |
| CHEMBL296908 | — | — | 1 | 7.63 |
| CHEMBL86667 | — | — | 1 | 7.49 |
| CHEMBL86577 | — | — | 1 | 7.20 |
| CHEMBL2112339 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307483 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL419667 | RELCOVAPTAN | Ki | = | 1.43 | nM | 8.85 |
| CHEMBL86949 | — | Ki | = | 9.69 | nM | 8.01 |
| CHEMBL89552 | — | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL296908 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL86667 | — | Ki | = | 32.4 | nM | 7.49 |
| CHEMBL86577 | — | Ki | = | 62.7 | nM | 7.20 |
| CHEMBL2112339 | — | Ki | = | 102.0 | nM | 6.99 |