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Compound Detail

CHEMBL86667

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Cc1cccc(OCc2ccc(C(=O)N3CCC(N4CCCCC4)CC3)cc2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL86667
Phase Preclinical
Structure Type MOL
InChI Key YNIKROKUPDMHIM-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

625.8
MW (Da)
7.89
ALogP
6
HBA
0
HBD
63.5
PSA (Ų)
0.18
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C40H43N5O2
MW 625.82
Aromatic Rings 5
Heavy Atoms 47
NP-Likeness -1.16

Activity Summary

Ki 4 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1a receptor
CHEMBL1889
Ki 9.0 9.0 1.0 1
Vasopressin V1a receptor
CHEMBL2868
Ki 7.49 7.49 32.4 1
Vasopressin V2 receptor
CHEMBL3766
Ki 5.74 5.74 1840.0 1
Vasopressin V2 receptor
CHEMBL1790
Ki 5.72 5.72 1920.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12036368 10.1021/jm010544r Vasopressin V2 receptor 3
12036368 10.1021/jm010544r Vasopressin V1a receptor 2
12036368 10.1021/jm010544r Unchecked 1

Data from ChEMBL 36 via Core Engine