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Compound Detail

CHEMBL2112339

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Cc1cccc(OCCCCCCN2CCN(C)CC2)c1-n1c(C)nnc1-c1ccc(-c2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL2112339
Phase Preclinical
Structure Type MOL
InChI Key WYFKUBJWMBRINL-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

523.7
MW (Da)
6.40
ALogP
6
HBA
0
HBD
46.4
PSA (Ų)
0.21
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C33H41N5O
MW 523.73
Aromatic Rings 4
Heavy Atoms 39
NP-Likeness -1.14

Activity Summary

Ki 4 meas. best 8.84

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1a receptor
CHEMBL1889
Ki 8.84 8.84 1.5 1
Vasopressin V1a receptor
CHEMBL2868
Ki 6.99 6.99 102.0 1
Vasopressin V2 receptor
CHEMBL3766
Ki 4.93 4.93 11700.0 1
Vasopressin V2 receptor
CHEMBL1790
Ki 4.84 4.84 14400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12036368 10.1021/jm010544r Vasopressin V2 receptor 3
12036368 10.1021/jm010544r Vasopressin V1a receptor 2
12036368 10.1021/jm010544r Unchecked 1

Data from ChEMBL 36 via Core Engine