Assay Detail
Binding
CHEMBL821185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Potassium voltage-gated channel subfamily A member 3 (CHEMBL4633) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 5.67 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311283 | CORREOLIDE | — | 1 | 7.00 |
| CHEMBL308029 | — | — | 1 | 6.55 |
| CHEMBL310916 | — | — | 1 | 6.40 |
| CHEMBL306931 | — | — | 1 | 6.25 |
| CHEMBL76997 | — | — | 1 | 6.22 |
| CHEMBL307016 | — | — | 1 | 6.17 |
| CHEMBL78325 | — | — | 1 | 6.16 |
| CHEMBL432341 | — | — | 1 | 6.16 |
| CHEMBL77926 | — | — | 1 | 6.10 |
| CHEMBL76543 | — | — | 1 | 6.10 |
| CHEMBL77317 | — | — | 1 | 6.09 |
| CHEMBL72328 | — | — | 1 | 6.00 |
| CHEMBL75091 | — | — | 1 | 6.00 |
| CHEMBL308554 | — | — | 1 | 5.82 |
| CHEMBL306037 | — | — | 1 | 5.70 |
| CHEMBL78004 | — | — | 1 | 5.52 |
| CHEMBL75159 | — | — | 1 | 5.51 |
| CHEMBL78267 | — | — | 1 | 5.46 |
| CHEMBL74306 | — | — | 1 | 5.40 |
| CHEMBL77493 | — | — | 1 | 5.30 |
| CHEMBL306038 | — | — | 1 | 5.15 |
| CHEMBL77572 | — | — | 1 | 5.00 |
| CHEMBL306708 | — | — | 1 | 4.77 |
| CHEMBL78293 | — | — | 1 | 4.30 |
| CHEMBL310762 | — | — | 1 | 4.16 |
| CHEMBL422416 | — | — | 1 | 4.00 |
| CHEMBL284348 | DALFAMPRIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311283 | CORREOLIDE | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL308029 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL310916 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL306931 | — | Kd | = | 560.0 | nM | 6.25 |
| CHEMBL76997 | — | Kd | = | 600.0 | nM | 6.22 |
| CHEMBL307016 | — | Kd | = | 680.0 | nM | 6.17 |
| CHEMBL78325 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL432341 | — | Kd | = | 700.0 | nM | 6.16 |
| CHEMBL77926 | — | Kd | = | 800.0 | nM | 6.10 |
| CHEMBL76543 | — | Kd | = | 800.0 | nM | 6.10 |
| CHEMBL77317 | — | Kd | = | 820.0 | nM | 6.09 |
| CHEMBL72328 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL75091 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL308554 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL306037 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL78004 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL75159 | — | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL78267 | — | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL74306 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL77493 | — | Kd | = | 5000.0 | nM | 5.30 |
| CHEMBL306038 | — | Kd | = | 7100.0 | nM | 5.15 |
| CHEMBL77572 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL306708 | — | Kd | = | 17000.0 | nM | 4.77 |
| CHEMBL78293 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL310762 | — | Kd | = | 70000.0 | nM | 4.16 |
| CHEMBL422416 | — | Kd | = | 100000.0 | nM | 4.00 |
| CHEMBL284348 | DALFAMPRIDINE | Kd | = | 195000.0 | nM | - |