Assay Detail
Binding
CHEMBL822187
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Binding affinity towards delta-opioid receptor by displacement of [3H]DADL in rat brain homogenates
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.06 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL982 | NALMEFENE | 4.0 | 1 | 8.47 |
| CHEMBL300662 | — | — | 1 | 8.28 |
| CHEMBL98507 | — | — | 1 | 7.99 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL982 | NALMEFENE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL300662 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL98507 | — | Ki | = | 10.27 | nM | 7.99 |
| CHEMBL80 | NALOXONE | Ki | = | 32.0 | nM | 7.50 |