Assay Detail
Functional
CHEMBL824948
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In vitro inhibitory concentration against bone resorption in 17 day old fetal mouse metatarsals
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.58 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 7.47 |
| CHEMBL193722 | — | — | 1 | 7.12 |
| CHEMBL193355 | — | — | 1 | 6.66 |
| CHEMBL193356 | — | — | 1 | 6.66 |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | 6.54 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 6.52 |
| CHEMBL363145 | — | — | 1 | 6.43 |
| CHEMBL192342 | — | — | 1 | 6.39 |
| CHEMBL191634 | — | — | 1 | 6.17 |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL193722 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL193355 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL193356 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL363145 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL192342 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL191634 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 1600.0 | nM | 5.80 |