Assay Detail
Binding
CHEMBL828842
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.61 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363414 | — | — | 1 | 8.54 |
| CHEMBL296641 | ANTALARMIN | — | 1 | 8.51 |
| CHEMBL195631 | — | — | 1 | 8.46 |
| CHEMBL364016 | — | — | 1 | 8.38 |
| CHEMBL195699 | — | — | 1 | 8.27 |
| CHEMBL427168 | — | — | 1 | 8.22 |
| CHEMBL195152 | — | — | 1 | 8.19 |
| CHEMBL371407 | — | — | 1 | 8.14 |
| CHEMBL309138 | — | — | 1 | 8.11 |
| CHEMBL370501 | — | — | 1 | 7.89 |
| CHEMBL194607 | — | — | 1 | 7.89 |
| CHEMBL372009 | — | — | 1 | 7.80 |
| CHEMBL191755 | — | — | 1 | 7.52 |
| CHEMBL191903 | — | — | 1 | 7.40 |
| CHEMBL371367 | — | — | 1 | 7.31 |
| CHEMBL192288 | — | — | 1 | 7.26 |
| CHEMBL192335 | — | — | 1 | 7.21 |
| CHEMBL192082 | — | — | 1 | 6.92 |
| CHEMBL434910 | — | — | 1 | 6.72 |
| CHEMBL191780 | — | — | 1 | 5.72 |
| CHEMBL191650 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363414 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL296641 | ANTALARMIN | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL195631 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL364016 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL195699 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL427168 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL195152 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL371407 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL309138 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL370501 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL194607 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL372009 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL191755 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL191903 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL371367 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL192288 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL192335 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL192082 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL434910 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL191780 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL191650 | — | Ki | = | 4100.0 | nM | 5.39 |