Assay Detail
Functional
CHEMBL834117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit electrically induced contraction of superfused guinea-pig trachea was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the beta2-adrenoceptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.49 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363260 | — | — | 1 | 8.96 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 8.85 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 7.82 |
| CHEMBL363329 | — | — | 1 | 7.42 |
| CHEMBL185052 | — | — | 1 | 7.15 |
| CHEMBL440561 | — | — | 1 | 6.94 |
| CHEMBL185262 | — | — | 1 | 6.92 |
| CHEMBL183948 | — | — | 1 | 6.79 |
| CHEMBL184538 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363260 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1256786 | FORMOTEROL | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1263 | SALMETEROL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL363329 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL185052 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL440561 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL185262 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL183948 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL184538 | — | IC50 | = | 251.0 | nM | 6.60 |