Assay Detail
Functional
CHEMBL836611
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Effective concentration required to reduce TK+ (thymidine kinase presence) VZV strain YS virus plaque formation by 50% in HEL cell culture
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.60 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.52 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.89 |
| CHEMBL186389 | — | — | 1 | 5.39 |
| CHEMBL189399 | — | — | 1 | - |
| CHEMBL188254 | — | — | 1 | - |
| CHEMBL188359 | — | — | 1 | - |
| CHEMBL185694 | — | — | 1 | - |
| CHEMBL364765 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL186389 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL189399 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL188254 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL188359 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL185694 | — | EC50 | > | 40000.0 | nM | - |
| CHEMBL364765 | — | EC50 | > | 40000.0 | nM | - |