Assay Detail
Binding
CHEMBL838679
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Inhibition of [3H]paroxetine binding to rat serotonin transporter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.41 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536952 | — | — | 1 | 8.14 |
| CHEMBL541124 | — | — | 1 | 7.73 |
| CHEMBL536264 | — | — | 1 | 7.68 |
| CHEMBL536265 | — | — | 1 | 6.90 |
| CHEMBL539076 | — | — | 1 | 6.56 |
| CHEMBL539845 | — | — | 1 | 6.51 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | 4.0 | 1 | 6.38 |
| CHEMBL536037 | — | — | 1 | 6.37 |
| CHEMBL557576 | — | — | 1 | 6.09 |
| CHEMBL539075 | — | — | 1 | 5.79 |
| CHEMBL540360 | — | — | 1 | 5.29 |
| CHEMBL537843 | — | — | 1 | 5.00 |
| CHEMBL536034 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536952 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL541124 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL536264 | — | Ki | = | 21.1 | nM | 7.68 |
| CHEMBL536265 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL539076 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL539845 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL1701 | MEPERIDINE HYDROCHLORIDE | Ki | = | 413.0 | nM | 6.38 |
| CHEMBL536037 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL557576 | — | Ki | = | 805.0 | nM | 6.09 |
| CHEMBL539075 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL540360 | — | Ki | = | 5110.0 | nM | 5.29 |
| CHEMBL537843 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL536034 | — | Ki | = | 13700.0 | nM | 4.86 |