Compound Detail
CHEMBL536265
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Basic Information
| ChEMBL ID | CHEMBL536265 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BGOHVVNAGKBHOC-UHFFFAOYSA-N |
| Parent Compound | CHEMBL109386 |
| Active Moiety | CHEMBL109386 |
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
250.3
MW (Da)
3.33
ALogP
2
HBA
0
HBD
27.0
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.9
IC50 2 meas. best 6.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter CHEMBL313 | Ki | 6.9 | 6.9 | 125.0 | 1 |
| Sodium-dependent dopamine transporter CHEMBL338 | IC50 | 6.43 | 5.545 | 370.0 | 2 |
| Sodium-dependent dopamine transporter CHEMBL338 | Ki | 5.63 | 5.63 | 2360.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 4.81 | 4.81 | 15400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Ki | = | 125.0 | nM | 6.9 | Inhibition of [3H]paroxetine binding to rat serotonin transporter | 15743177 |
| Sodium-dependent dopamine transporter | IC50 | = | 370.0 | nM | 6.43 | Inhibitory concentration against [3H]DA uptake in rat brain tissue | 15743177 |
| Sodium-dependent dopamine transporter | Ki | = | 2360.0 | nM | 5.63 | Inhibition of [3H]WIN-35428 binding to rat dopamine transporter | 15743177 |
| Mu-type opioid receptor | Ki | = | 15400.0 | nM | 4.81 | Inhibition of [3H]DAMGO binding to mu-opioid receptor at 100 uM | 15743177 |
| Sodium-dependent dopamine transporter | IC50 | = | 21800.0 | nM | 4.66 | Inhibitory concentration against [3H]DA uptake in rat brain tissue | 15743177 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15743177 | 10.1021/jm0401614 | Sodium-dependent dopamine transporter | 4 |
| 15743177 | 10.1021/jm0401614 | Unchecked | 2 |
| 15743177 | 10.1021/jm0401614 | Mu-type opioid receptor | 2 |
| 15743177 | 10.1021/jm0401614 | Sodium-dependent serotonin transporter | 1 |
| 15743177 | 10.1021/jm0401614 | Norepinephrine transporter | 1 |
| 15743177 | 10.1021/jm0401614 | Monoamine transporters; serotonin & dopamine | 1 |
Data from ChEMBL 36 via Core Engine