Assay Detail
Binding
CHEMBL838819
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Binding affinity against human cytosolic Carbonic anhydrase II
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.87 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368444 | — | — | 1 | 5.22 |
| CHEMBL1356 | SODIUM BENZOATE | 4.0 | 1 | 4.52 |
| CHEMBL1353 | SODIUM BICARBONATE | 4.0 | 1 | - |
| CHEMBL183491 | SODIUM FORMATE | — | 1 | - |
| CHEMBL1354 | SODIUM ACETATE | 4.0 | 1 | - |
| CHEMBL182928 | SODIUM OXALATE | — | 1 | - |
| CHEMBL359504 | DISODIUM MALONATE | — | 1 | - |
| CHEMBL181886 | PYRUVATE SODIUM | 2.0 | 1 | - |
| CHEMBL1357 | SODIUM LACTATE | 4.0 | 1 | - |
| CHEMBL182856 | E350 | — | 1 | - |
| CHEMBL1355 | SODIUM CITRATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368444 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL1356 | SODIUM BENZOATE | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL1353 | SODIUM BICARBONATE | Ki | = | 85000000.0 | nM | - |
| CHEMBL183491 | SODIUM FORMATE | Ki | = | 24000000.0 | nM | - |
| CHEMBL1354 | SODIUM ACETATE | Ki | = | 130000.0 | nM | - |
| CHEMBL182928 | SODIUM OXALATE | Ki | = | 990000.0 | nM | - |
| CHEMBL359504 | DISODIUM MALONATE | Ki | = | 1620000.0 | nM | - |
| CHEMBL181886 | PYRUVATE SODIUM | Ki | = | 2110000.0 | nM | - |
| CHEMBL1357 | SODIUM LACTATE | Ki | = | 3220000.0 | nM | - |
| CHEMBL182856 | E350 | Ki | = | 1870000.0 | nM | - |
| CHEMBL1355 | SODIUM CITRATE | Ki | = | 2160000.0 | nM | - |