Assay Detail
Binding
CHEMBL842149
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compound was tested for inhibitory activity against Urokinase-type plasminogen activator (microPa)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.51 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30044 | DIBROMPROPAMIDINE | 2.0 | 1 | 5.80 |
| CHEMBL26856 | — | — | 1 | 5.71 |
| CHEMBL26370 | — | — | 1 | 5.70 |
| CHEMBL25105 | HEXAMIDINE | 2.0 | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30044 | DIBROMPROPAMIDINE | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL26856 | — | Ki | = | 1950.0 | nM | 5.71 |
| CHEMBL26370 | — | Ki | = | 1980.0 | nM | 5.70 |
| CHEMBL25105 | HEXAMIDINE | Ki | = | 14400.0 | nM | 4.84 |