Compound Detail
CHEMBL30044
DIBROMPROPAMIDINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL30044 |
| Name | DIBROMPROPAMIDINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | GMJFVGRUYJHMCO-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
3
Known Names
1
Indications
Molecular Properties
470.2
MW (Da)
3.63
ALogP
4
HBA
4
HBD
118.2
PSA (Ų)
0.27
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Eye Infections
ATC Classification
D08AC01
dibrompropamidine
Level 1: DERMATOLOGICALS
Level 2: ANTISEPTICS AND DISINFECTANTS
S01AX14
dibrompropamidine
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
Activity Summary
Ki 4 meas. best 6.27
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Suppressor of tumorigenicity 14 protein CHEMBL3018 | Ki | 6.27 | 6.27 | 535.0 | 1 |
| Prothrombin CHEMBL204 | Ki | 6.02 | 6.02 | 946.0 | 1 |
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 5.8 | 5.8 | 1570.0 | 1 |
| Acrosin CHEMBL3243910 | Ki | 5.77 | 5.77 | 1700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Suppressor of tumorigenicity 14 protein | Ki | = | 535.0 | nM | 6.27 | compound was tested for inhibitory activity against Matriptase | 11311057 |
| Prothrombin | Ki | = | 946.0 | nM | 6.02 | compound was tested for inhibitory activity against Thrombin | 11311057 |
| Urokinase-type plasminogen activator | Ki | = | 1570.0 | nM | 5.8 | compound was tested for inhibitory activity against Urokinase-type plasminogen a... | 11311057 |
| Acrosin | Ki | = | 1700.0 | nM | 5.77 | Reversible competitive inhibition of boar spermatozoa acrosin using BzArgOEt as ... | 722718 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11311057 | 10.1021/jm000395x | Suppressor of tumorigenicity 14 protein | 1 |
| 11311057 | 10.1021/jm000395x | Urokinase-type plasminogen activator | 1 |
| 11311057 | 10.1021/jm000395x | Prothrombin | 1 |
| 722718 | 10.1021/jm00209a008 | Acrosin | 1 |
Data from ChEMBL 36 via Core Engine