Assay Detail
Binding
CHEMBL718140
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compound was tested for inhibitory activity against Matriptase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Suppressor of tumorigenicity 14 protein (CHEMBL3018) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.17 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26370 | — | — | 1 | 6.72 |
| CHEMBL26856 | — | — | 1 | 6.68 |
| CHEMBL30044 | DIBROMPROPAMIDINE | 2.0 | 1 | 6.27 |
| CHEMBL25105 | HEXAMIDINE | 2.0 | 1 | 6.03 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.94 |
| CHEMBL27421 | — | — | 1 | 5.35 |
| CHEMBL285114 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26370 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL26856 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL30044 | DIBROMPROPAMIDINE | Ki | = | 535.0 | nM | 6.27 |
| CHEMBL25105 | HEXAMIDINE | Ki | = | 924.0 | nM | 6.03 |
| CHEMBL55 | PENTAMIDINE | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL27421 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL285114 | — | Ki | > | 10000.0 | nM | - |