Compound Detail
CHEMBL26856
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Basic Information
| ChEMBL ID | CHEMBL26856 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JARPXSXRDFAPLC-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
3.84
ALogP
4
HBA
4
HBD
118.2
PSA (Ų)
0.40
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Suppressor of tumorigenicity 14 protein CHEMBL3018 | Ki | 6.7 | 6.69 | 200.0 | 2 |
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 5.71 | 5.71 | 1950.0 | 1 |
| Prothrombin CHEMBL204 | Ki | 5.57 | 5.57 | 2670.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Suppressor of tumorigenicity 14 protein | Ki | = | 200.0 | nM | 6.7 | Inhibition of recombinant matriptase (unknown origin) using Boc-Gln-Ala-Arg-7-am... | 24794746 |
| Suppressor of tumorigenicity 14 protein | Ki | = | 208.0 | nM | 6.68 | compound was tested for inhibitory activity against Matriptase | 11311057 |
| Urokinase-type plasminogen activator | Ki | = | 1950.0 | nM | 5.71 | compound was tested for inhibitory activity against Urokinase-type plasminogen a... | 11311057 |
| Prothrombin | Ki | = | 2670.0 | nM | 5.57 | compound was tested for inhibitory activity against Thrombin | 11311057 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11311057 | 10.1021/jm000395x | Suppressor of tumorigenicity 14 protein | 1 |
| 11311057 | 10.1021/jm000395x | Urokinase-type plasminogen activator | 1 |
| 11311057 | 10.1021/jm000395x | Prothrombin | 1 |
| 24794746 | 10.1016/j.bmc.2014.04.013 | Suppressor of tumorigenicity 14 protein | 1 |
Data from ChEMBL 36 via Core Engine