Compound Detail
CHEMBL26370
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Basic Information
| ChEMBL ID | CHEMBL26370 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DXAJHYNCKDFWAU-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
480.4
MW (Da)
3.88
ALogP
4
HBA
4
HBD
118.2
PSA (Ų)
0.17
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Suppressor of tumorigenicity 14 protein CHEMBL3018 | Ki | 6.72 | 6.72 | 191.0 | 1 |
| Prothrombin CHEMBL204 | Ki | 6.1 | 6.1 | 796.0 | 1 |
| Urokinase-type plasminogen activator CHEMBL3286 | Ki | 5.7 | 5.7 | 1980.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Suppressor of tumorigenicity 14 protein | Ki | = | 191.0 | nM | 6.72 | compound was tested for inhibitory activity against Matriptase | 11311057 |
| Prothrombin | Ki | = | 796.0 | nM | 6.1 | compound was tested for inhibitory activity against Thrombin | 11311057 |
| Urokinase-type plasminogen activator | Ki | = | 1980.0 | nM | 5.7 | compound was tested for inhibitory activity against Urokinase-type plasminogen a... | 11311057 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11311057 | 10.1021/jm000395x | Suppressor of tumorigenicity 14 protein | 1 |
| 11311057 | 10.1021/jm000395x | Urokinase-type plasminogen activator | 1 |
| 11311057 | 10.1021/jm000395x | Prothrombin | 1 |
Data from ChEMBL 36 via Core Engine