Assay Detail
Functional
CHEMBL844625
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Leukotriene (LTB4) biosynthesis in isolated human polymorphonuclear cells (PMNs)
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.51 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7267 | — | — | 1 | 8.05 |
| CHEMBL7273 | — | — | 1 | 7.72 |
| CHEMBL266116 | — | — | 1 | 7.72 |
| CHEMBL266777 | — | — | 1 | 7.55 |
| CHEMBL266721 | — | — | 1 | 7.55 |
| CHEMBL7685 | — | — | 1 | 7.33 |
| CHEMBL273767 | — | — | 1 | 7.29 |
| CHEMBL7351 | — | — | 1 | 7.26 |
| CHEMBL266053 | — | — | 1 | 7.24 |
| CHEMBL266547 | — | — | 1 | 7.22 |
| CHEMBL7477 | — | — | 1 | 7.19 |
| CHEMBL7678 | — | — | 1 | 7.18 |
| CHEMBL7097 | — | — | 1 | 7.17 |
| CHEMBL266052 | — | — | 1 | 7.15 |
| CHEMBL7675 | — | — | 1 | 6.96 |
| CHEMBL7734 | — | — | 1 | 6.92 |
| CHEMBL7647 | — | — | 1 | 6.92 |
| CHEMBL7145 | — | — | 1 | 6.92 |
| CHEMBL7601 | — | — | 1 | 6.89 |
| CHEMBL7657 | — | — | 1 | 6.85 |
| CHEMBL7619 | — | — | 1 | 6.85 |
| CHEMBL7745 | — | — | 1 | 6.80 |
| CHEMBL269760 | — | — | 1 | 6.75 |
| CHEMBL412900 | — | — | 1 | 6.55 |
| CHEMBL7491 | — | — | 1 | 6.55 |
| CHEMBL7399 | — | — | 1 | 6.54 |
| CHEMBL7711 | — | — | 1 | 6.54 |
| CHEMBL268586 | — | — | 1 | 6.54 |
| CHEMBL266592 | — | — | 1 | 6.52 |
| CHEMBL7107 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7267 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL7273 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL266116 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL266777 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL266721 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL7685 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL273767 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL7351 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL266053 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL266547 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL7477 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL7678 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL7097 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL266052 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL7675 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL7734 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL7145 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL7647 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL7601 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL7657 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL7619 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL7745 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL269760 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL412900 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL7491 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL7399 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL268586 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL7711 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL266592 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL7107 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL7103 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL440452 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL269588 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL267272 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL7727 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL275295 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL7507 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL267472 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267867 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL7589 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL267470 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL267287 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7606 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL7517 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL7099 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL274302 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL7696 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL7311 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL7123 | — | IC50 | = | 10000.0 | nM | 5.00 |