Assay Detail
Binding
CHEMBL847432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against eubacterial tRNA guanine transglycosylase (TGT) from Zymomonas mobilis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zymomonas mobilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Queuine tRNA-ribosyltransferase (CHEMBL2987) ↗| Type | SINGLE PROTEIN |
| Organism | Zymomonas mobilis (strain ATCC 31821 / ZM4 / CP4) |
Publication
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.37 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14926 | — | — | 1 | 7.00 |
| CHEMBL14913 | — | — | 1 | 6.60 |
| CHEMBL418720 | — | — | 1 | 6.52 |
| CHEMBL278009 | PTERINE | — | 1 | 6.22 |
| CHEMBL276808 | — | — | 1 | 5.57 |
| CHEMBL277561 | — | — | 1 | 5.42 |
| CHEMBL277134 | — | — | 1 | 5.33 |
| CHEMBL278733 | — | — | 1 | 5.30 |
| CHEMBL14996 | — | — | 1 | 5.09 |
| CHEMBL14882 | — | — | 1 | 5.08 |
| CHEMBL442329 | — | — | 1 | 4.44 |
| CHEMBL14940 | — | — | 1 | 4.43 |
| CHEMBL277783 | — | — | 1 | 4.14 |
| CHEMBL280051 | — | — | 1 | 4.08 |
| CHEMBL15221 | — | — | 1 | - |
| CHEMBL15047 | — | — | 1 | - |
| CHEMBL275408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14926 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL14913 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL418720 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL278009 | PTERINE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL276808 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL277561 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL277134 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL278733 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL14996 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL14882 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL442329 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL14940 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL277783 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL280051 | — | Ki | = | 83000.0 | nM | 4.08 |
| CHEMBL15221 | — | Ki | = | 156000.0 | nM | - |
| CHEMBL15047 | — | Ki | = | 200000.0 | nM | - |
| CHEMBL275408 | — | Ki | = | 249000.0 | nM | - |