Assay Detail
ADMET
CHEMBL856833
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Inhibition of CYP2D6 in human liver microsomes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.73 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 6.39 |
| CHEMBL218068 | — | — | 1 | 5.89 |
| CHEMBL220660 | — | — | 1 | 5.77 |
| CHEMBL218067 | — | — | 1 | 5.77 |
| CHEMBL219060 | — | — | 1 | 4.82 |
| CHEMBL219113 | — | — | 1 | - |
| CHEMBL218547 | — | — | 1 | - |
| CHEMBL435316 | — | — | 1 | - |
| CHEMBL218017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1294 | QUINIDINE | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL218068 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL220660 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL218067 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL219060 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL219113 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL218547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL435316 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL218017 | — | IC50 | > | 25000.0 | nM | - |