Assay Detail
Functional
CHEMBL858286
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Loss of righting reflex (LORR) in tadpoles was determined for anesthetic activity
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Tissue | Tadpole |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 4.85 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109956 | — | — | 1 | 6.40 |
| CHEMBL526 | PROPOFOL | 4.0 | 1 | 5.70 |
| CHEMBL109774 | — | — | 1 | 5.00 |
| CHEMBL30014 | — | — | 1 | 4.70 |
| CHEMBL29790 | — | — | 1 | 4.50 |
| CHEMBL111740 | — | — | 1 | 4.30 |
| CHEMBL30106 | — | — | 1 | 4.20 |
| CHEMBL321841 | — | — | 1 | 4.00 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | - |
| CHEMBL111084 | — | — | 1 | - |
| CHEMBL109470 | — | — | 1 | - |
| CHEMBL109652 | SYRINGOL | — | 1 | - |
| CHEMBL112891 | — | — | 1 | - |
| CHEMBL54049 | — | — | 1 | - |
| CHEMBL111762 | — | — | 1 | - |
| CHEMBL111140 | — | — | 1 | - |
| CHEMBL29873 | — | — | 1 | - |
| CHEMBL111766 | — | — | 1 | - |
| CHEMBL111198 | — | — | 1 | - |
| CHEMBL109663 | — | — | 1 | - |
| CHEMBL321211 | — | — | 1 | - |
| CHEMBL281071 | — | — | 1 | - |
| CHEMBL30018 | — | — | 1 | - |
| CHEMBL31352 | — | — | 1 | - |
| CHEMBL111194 | — | — | 1 | - |
| CHEMBL111507 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109956 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL526 | PROPOFOL | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL109774 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL30014 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL29790 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL111740 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL30106 | — | EC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL321841 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL14060 | PHENOL | EC50 | = | 1584893.19 | nM | - |
| CHEMBL111084 | — | EC50 | = | 158489.32 | nM | - |
| CHEMBL109470 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL109652 | SYRINGOL | EC50 | = | 100000000.0 | nM | - |
| CHEMBL112891 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL54049 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111762 | — | EC50 | = | 158489.32 | nM | - |
| CHEMBL111140 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL29873 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111766 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111198 | — | EC50 | = | 158489.32 | nM | - |
| CHEMBL109663 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL321211 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL281071 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL30018 | — | EC50 | = | 125892.54 | nM | - |
| CHEMBL31352 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111194 | — | EC50 | = | 100000000.0 | nM | - |
| CHEMBL111507 | — | EC50 | = | 100000000.0 | nM | - |