Assay Detail
Functional
CHEMBL858933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of transactivation of human VDR in COS7 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Vitamin D receptor: ligand recognition and allosteric network.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.46 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263638 | — | — | 1 | 6.52 |
| CHEMBL3350951 | — | — | 1 | 6.40 |
| CHEMBL442191 | — | — | 1 | - |
| CHEMBL3350836 | — | — | 1 | - |
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | - |
| CHEMBL432600 | LEXACALCITOL | 2.0 | 1 | - |
| CHEMBL605525 | DP001 | 2.0 | 1 | - |
| CHEMBL383902 | — | — | 1 | - |
| CHEMBL2104955 | BECOCALCIDIOL | 2.0 | 1 | - |
| CHEMBL1478 | LITHOCHOLIC ACID | — | 1 | - |
| CHEMBL410893 | — | — | 1 | - |
| CHEMBL3350950 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263638 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3350951 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL442191 | — | IC50 | - | — | - | |
| CHEMBL3350836 | — | IC50 | - | — | - | |
| CHEMBL846 | CALCITRIOL | IC50 | - | — | - | |
| CHEMBL432600 | LEXACALCITOL | IC50 | - | — | - | |
| CHEMBL605525 | DP001 | IC50 | - | — | - | |
| CHEMBL383902 | — | IC50 | - | — | - | |
| CHEMBL2104955 | BECOCALCIDIOL | IC50 | - | — | - | |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | - | — | - | |
| CHEMBL410893 | — | IC50 | - | — | - | |
| CHEMBL3350950 | — | IC50 | - | — | - |