Assay Detail
Functional
CHEMBL867411
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Negative inotropic activity in guinea pig left atrium
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Calcium channel antagonists discovered by a multidisciplinary approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.11 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL211204 | — | — | 1 | 7.40 |
| CHEMBL441691 | — | — | 1 | 7.16 |
| CHEMBL383974 | — | — | 1 | 6.52 |
| CHEMBL212643 | — | — | 1 | 6.51 |
| CHEMBL213369 | — | — | 1 | 6.51 |
| CHEMBL386435 | — | — | 1 | 6.50 |
| CHEMBL384740 | — | — | 1 | 6.44 |
| CHEMBL379632 | — | — | 1 | 6.40 |
| CHEMBL386662 | — | — | 1 | 6.14 |
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.10 |
| CHEMBL377116 | — | — | 1 | 6.05 |
| CHEMBL215713 | — | — | 1 | 6.04 |
| CHEMBL384182 | — | — | 1 | 6.04 |
| CHEMBL383927 | — | — | 1 | 6.00 |
| CHEMBL378336 | — | — | 1 | 6.00 |
| CHEMBL215552 | — | — | 1 | 5.93 |
| CHEMBL214488 | — | — | 1 | 5.88 |
| CHEMBL379005 | — | — | 1 | 5.86 |
| CHEMBL214436 | — | — | 1 | 5.64 |
| CHEMBL384633 | — | — | 1 | 5.59 |
| CHEMBL379195 | — | — | 1 | 5.41 |
| CHEMBL214743 | — | — | 1 | 5.21 |
| CHEMBL213021 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL211204 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL441691 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL383974 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL212643 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL213369 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL386435 | — | EC50 | = | 313.0 | nM | 6.50 |
| CHEMBL384740 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL379632 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL386662 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL23 | DILTIAZEM | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL377116 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL215713 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL384182 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL383927 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL378336 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL215552 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL214488 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL379005 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL214436 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL384633 | — | EC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL379195 | — | EC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL214743 | — | EC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL213021 | — | EC50 | = | 7510.0 | nM | 5.12 |