Assay Detail
Functional
CHEMBL869180
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Antagonist activity against calcium channel assessed as inhibition of calcium-induced contraction of potassium ion-depolarized guinea pig ileum longitudinal smooth muscle
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Calcium channel antagonists discovered by a multidisciplinary approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.73 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.96 |
| CHEMBL212643 | — | — | 1 | 5.93 |
| CHEMBL215713 | — | — | 1 | 5.18 |
| CHEMBL386435 | — | — | 1 | 4.85 |
| CHEMBL379632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL212643 | — | EC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL215713 | — | EC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL386435 | — | EC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL379632 | — | EC50 | = | 124480.0 | nM | - |