Assay Detail
Functional
CHEMBL869181
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Antagonist activity against calcium channel assessed as inhibition of carbachol-induced tonic contraction of guinea pig ileum longitudinal smooth muscle
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Calcium channel antagonists discovered by a multidisciplinary approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.95 | 6.32 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 6.32 |
| CHEMBL212643 | — | — | 1 | 5.09 |
| CHEMBL215713 | — | — | 1 | 4.47 |
| CHEMBL386435 | — | — | 1 | 4.46 |
| CHEMBL211204 | — | — | 1 | 4.40 |
| CHEMBL379632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL212643 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL215713 | — | IC50 | = | 33660.0 | nM | 4.47 |
| CHEMBL386435 | — | IC50 | = | 34470.0 | nM | 4.46 |
| CHEMBL211204 | — | IC50 | = | 39950.0 | nM | 4.40 |
| CHEMBL379632 | — | Activity | - | — | - |