Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL869198

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against Plasmodium falciparum K1
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Ismail MA, Arafa RK, Brun R, Wenzler T, Miao Y, Wilson WD, Generaux C, Bridges A, Hall JE, Boykin DW.
J Med Chem (2006) 49 : 5324 -5332
PubMed 16913722 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.34 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL211920 1 6.30
CHEMBL424711 1 6.00
CHEMBL212783 1 6.00
CHEMBL215692 1 6.00
CHEMBL373412 1 5.00
CHEMBL215484 1 5.00
CHEMBL213259 1 5.00
CHEMBL377818 1 4.82
CHEMBL24057 FURAMIDINE -1.0 1 4.81
CHEMBL379577 1 4.43
CHEMBL215830 1 -
CHEMBL212556 1 -
CHEMBL215698 1 -
CHEMBL215714 1 -
CHEMBL211927 1 -
CHEMBL378834 1 -
CHEMBL214493 1 -
CHEMBL211981 1 -
CHEMBL213047 1 -
CHEMBL380213 1 -
CHEMBL212805 1 -
CHEMBL55 PENTAMIDINE 4.0 1 -
CHEMBL213573 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL211920 IC50 = 500.0 nM 6.30
CHEMBL424711 IC50 = 1000.0 nM 6.00
CHEMBL212783 IC50 = 1000.0 nM 6.00
CHEMBL215692 IC50 = 1000.0 nM 6.00
CHEMBL373412 IC50 = 10000.0 nM 5.00
CHEMBL215484 IC50 = 10000.0 nM 5.00
CHEMBL213259 IC50 = 10000.0 nM 5.00
CHEMBL377818 IC50 = 15000.0 nM 4.82
CHEMBL24057 FURAMIDINE IC50 = 15500.0 nM 4.81
CHEMBL379577 IC50 = 37000.0 nM 4.43
CHEMBL215830 IC50 > 11800000.0 nM -
CHEMBL212556 IC50 = 371000.0 nM -
CHEMBL215698 IC50 = 925000.0 nM -
CHEMBL215714 IC50 = 4200000.0 nM -
CHEMBL211927 IC50 = 3100000.0 nM -
CHEMBL378834 IC50 = 3800000.0 nM -
CHEMBL214493 IC50 = 7600000.0 nM -
CHEMBL211981 IC50 = 5700000.0 nM -
CHEMBL213047 IC50 = 1200000.0 nM -
CHEMBL380213 IC50 = 6600000.0 nM -
CHEMBL212805 IC50 = 1600000.0 nM -
CHEMBL55 PENTAMIDINE IC50 - -
CHEMBL213573 IC50 = 3200000.0 nM -