Assay Detail
Functional
CHEMBL869220
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Vasorelaxant activity assessed as inhibition of calcium-induced contraction of potassium ion-depolarized guinea pig aortic strips
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Calcium channel antagonists discovered by a multidisciplinary approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.05 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | 4.0 | 1 | 5.58 |
| CHEMBL212643 | — | — | 1 | 5.25 |
| CHEMBL213369 | — | — | 1 | 4.75 |
| CHEMBL214488 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23 | DILTIAZEM | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL212643 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL213369 | — | IC50 | = | 17710.0 | nM | 4.75 |
| CHEMBL214488 | — | IC50 | = | 25100.0 | nM | 4.60 |