Assay Detail
Binding
CHEMBL872900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]estradiol from Estrogen receptor alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.97 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315474 | — | — | 1 | 9.44 |
| CHEMBL315475 | — | — | 1 | 8.60 |
| CHEMBL432371 | — | — | 1 | 8.42 |
| CHEMBL314561 | — | — | 1 | 7.50 |
| CHEMBL86206 | — | — | 1 | 7.47 |
| CHEMBL85561 | — | — | 1 | 7.22 |
| CHEMBL316003 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315474 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL315475 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL432371 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL314561 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL86206 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL85561 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL316003 | — | Ki | = | 75.0 | nM | 7.12 |