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Compound Detail

CHEMBL316003

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CCc1c(-c2ccc(O)cc2)oc(-c2ccc(O)cc2)c1-c1ccc(OCCN2CCCCC2)cc1

Basic Information

ChEMBL ID CHEMBL316003
Phase Preclinical
Structure Type MOL
InChI Key OAJSYSKCXTXABR-UHFFFAOYSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

483.6
MW (Da)
7.12
ALogP
5
HBA
2
HBD
66.1
PSA (Ų)
0.28
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H33NO4
MW 483.61
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -0.20

Activity Summary

IC50 2 meas. best 7.19
Ki 2 meas. best 8.51

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Estrogen receptor beta
CHEMBL242
Ki 8.51 8.51 3.1 1
Estrogen receptor
CHEMBL206
IC50 7.19 7.19 65.0 1
Estrogen receptor
CHEMBL206
Ki 7.12 7.12 75.0 1
Estrogen receptor beta
CHEMBL242
IC50 6.32 6.32 480.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11549460 10.1016/s0960-894x(01)00488-7 Estrogen receptor 3
11549460 10.1016/s0960-894x(01)00488-7 Estrogen receptor beta 2

Data from ChEMBL 36 via Core Engine