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Compound Detail

CHEMBL314561

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Cc1c(-c2ccc(O)cc2)oc(-c2ccc(O)cc2)c1-c1ccc(OCCN2CCCCC2)cc1

Basic Information

ChEMBL ID CHEMBL314561
Phase Preclinical
Structure Type MOL
InChI Key TUWAJCMXXFZLOS-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

469.6
MW (Da)
6.86
ALogP
5
HBA
2
HBD
66.1
PSA (Ų)
0.31
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H31NO4
MW 469.58
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -0.22

Activity Summary

Ki 2 meas. best 9.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Estrogen receptor beta
CHEMBL242
Ki 9.33 9.33 0.5 1
Estrogen receptor
CHEMBL206
Ki 7.5 7.5 32.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11549460 10.1016/s0960-894x(01)00488-7 Estrogen receptor 2
11549460 10.1016/s0960-894x(01)00488-7 Estrogen receptor beta 1

Data from ChEMBL 36 via Core Engine