Assay Detail
Functional
CHEMBL874368
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Cytotoxicity against A2780-CP3, cisplatin-resistant Ovarian carcinoma cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.80 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339531 | — | — | 1 | 9.44 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.85 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.39 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.25 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339531 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 9000.0 | nM | 5.05 |