Assay Detail
Functional
CHEMBL875015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional activity against adenosine A2a receptor from rat aorta.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 6.14 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605265 | — | — | 1 | 7.54 |
| CHEMBL603596 | — | — | 1 | 6.96 |
| CHEMBL331372 | CGS-21680 | — | 1 | 6.94 |
| CHEMBL605690 | — | — | 1 | 6.68 |
| CHEMBL604026 | — | — | 1 | 6.65 |
| CHEMBL606318 | — | — | 1 | 6.61 |
| CHEMBL604019 | — | — | 1 | 6.52 |
| CHEMBL464859 | NECA | — | 1 | 6.41 |
| CHEMBL604851 | — | — | 1 | 6.39 |
| CHEMBL603809 | — | — | 1 | 6.39 |
| CHEMBL2113449 | — | — | 1 | 6.36 |
| CHEMBL605057 | — | — | 1 | 6.33 |
| CHEMBL603812 | — | — | 1 | 6.31 |
| CHEMBL2113450 | — | — | 1 | 6.30 |
| CHEMBL604440 | — | — | 1 | 6.28 |
| CHEMBL410873 | — | — | 1 | 6.22 |
| CHEMBL603602 | — | — | 1 | 6.18 |
| CHEMBL606319 | — | — | 1 | 6.12 |
| CHEMBL604234 | — | — | 1 | 5.92 |
| CHEMBL605473 | — | — | 1 | 5.89 |
| CHEMBL605478 | — | — | 1 | 5.87 |
| CHEMBL223270 | — | — | 1 | 5.82 |
| CHEMBL603808 | — | — | 1 | 5.78 |
| CHEMBL604647 | — | — | 1 | 5.52 |
| CHEMBL605685 | — | — | 1 | 5.48 |
| CHEMBL604849 | — | — | 1 | 5.46 |
| CHEMBL605055 | — | — | 1 | 5.45 |
| CHEMBL604023 | — | — | 1 | 5.39 |
| CHEMBL606315 | — | — | 1 | 5.19 |
| CHEMBL605264 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605265 | — | EC50 | = | 28.7 | nM | 7.54 |
| CHEMBL603596 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL331372 | CGS-21680 | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL605690 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL604026 | — | EC50 | = | 223.0 | nM | 6.65 |
| CHEMBL606318 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL604019 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL464859 | NECA | EC50 | = | 394.0 | nM | 6.41 |
| CHEMBL604851 | — | EC50 | = | 406.0 | nM | 6.39 |
| CHEMBL603809 | — | EC50 | = | 408.0 | nM | 6.39 |
| CHEMBL2113449 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL605057 | — | EC50 | = | 468.0 | nM | 6.33 |
| CHEMBL603812 | — | EC50 | = | 491.0 | nM | 6.31 |
| CHEMBL2113450 | — | EC50 | = | 497.0 | nM | 6.30 |
| CHEMBL604440 | — | EC50 | = | 531.0 | nM | 6.28 |
| CHEMBL410873 | — | EC50 | = | 596.0 | nM | 6.22 |
| CHEMBL603602 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL606319 | — | EC50 | = | 753.0 | nM | 6.12 |
| CHEMBL604234 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL605473 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL605478 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL223270 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL603808 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL604647 | — | EC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL605685 | — | EC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL604849 | — | EC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL605055 | — | EC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL604023 | — | EC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL606315 | — | EC50 | = | 6420.0 | nM | 5.19 |
| CHEMBL605264 | — | EC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL605065 | — | EC50 | = | 0.008 | nM | - |
| CHEMBL284969 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL605691 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL603389 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL605056 | — | EC50 | > | 10.0 | nM | - |