Assay Detail
Functional
CHEMBL875956
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In vitro cytotoxicity was tested against human Ovarian carcinoma A2780 cell line
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2,3-Dihydro-1H,7H-pyrimido[5,6,1-de]acridine-1,3,7-trione derivatives, a class of cytotoxic agents active on multidrug-resistant cell lines: synthesis, biological evaluation, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.97 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544311 | — | — | 1 | 8.39 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.02 |
| CHEMBL553593 | — | — | 1 | 7.68 |
| CHEMBL553744 | — | — | 1 | 7.66 |
| CHEMBL85471 | — | — | 1 | 7.64 |
| CHEMBL82722 | — | — | 1 | 7.34 |
| CHEMBL83620 | — | — | 1 | 6.96 |
| CHEMBL84219 | — | — | 1 | 6.92 |
| CHEMBL85087 | — | — | 1 | 6.85 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.05 |
| CHEMBL432951 | — | — | 1 | 5.80 |
| CHEMBL82952 | — | — | 1 | 5.68 |
| CHEMBL83128 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544311 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL553593 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL553744 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL85471 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL82722 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL83620 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL84219 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL85087 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL432951 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL82952 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL83128 | — | IC50 | = | 2100.0 | nM | 5.68 |