Assay Detail
Functional
CHEMBL878183
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Compound was evaluated for antiproliferative activity against human ovarian carcinoma cell line A2780.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.32 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 8.47 |
| CHEMBL63175 | — | — | 1 | 6.87 |
| CHEMBL434022 | — | — | 1 | 6.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL63175 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL434022 | — | IC50 | = | 234.0 | nM | 6.63 |