Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL882020

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against OKA strain of VZV in HEL (human erythroleukemia) cells.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Cell Type HEL
Confidence 1 — Organism
Curated By Expert

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
Hocková D, Holý A, Masojídková M, Andrei G, Snoeck R, De Clercq E, Balzarini J.
J Med Chem (2003) 46 : 5064 -5073
PubMed 14584956 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 5.35 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL346387 1 6.77
CHEMBL298845 1 5.35
CHEMBL342983 1 4.75
CHEMBL484 ADEFOVIR 3.0 1 4.52
CHEMBL356695 1 -
CHEMBL146699 1 -
CHEMBL150124 1 -
CHEMBL149116 1 -
CHEMBL149197 1 -
CHEMBL356135 1 -
CHEMBL149664 1 -
CHEMBL150057 1 -
CHEMBL148716 1 -
CHEMBL147814 1 -
CHEMBL348215 1 -
CHEMBL146197 1 -
CHEMBL483 TENOFOVIR ANHYDROUS 3.0 1 -
CHEMBL148304 1 -
CHEMBL146182 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL346387 EC50 = 170.0 nM 6.77
CHEMBL298845 EC50 = 4500.0 nM 5.35
CHEMBL342983 EC50 = 18000.0 nM 4.75
CHEMBL484 ADEFOVIR EC50 = 30000.0 nM 4.52
CHEMBL356695 EC50 > 150000.0 nM -
CHEMBL146699 EC50 = 140000.0 nM -
CHEMBL150124 EC50 > 150000.0 nM -
CHEMBL149116 EC50 > 150000.0 nM -
CHEMBL149197 EC50 > 150000.0 nM -
CHEMBL356135 EC50 - nM -
CHEMBL149664 EC50 > 150000.0 nM -
CHEMBL150057 EC50 > 150000.0 nM -
CHEMBL148716 EC50 > 150000.0 nM -
CHEMBL147814 EC50 > 150000.0 nM -
CHEMBL348215 EC50 > 150000.0 nM -
CHEMBL146197 EC50 > 150000.0 nM -
CHEMBL483 TENOFOVIR ANHYDROUS EC50 = 170000.0 nM -
CHEMBL148304 EC50 > 150000.0 nM -
CHEMBL146182 EC50 > 150000.0 nM -