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Assay Detail

CHEMBL884235

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration to show 50% of activity was measured on herpes simplex virus-1 KOS strain cell culture.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
Choi Y, Li L, Grill S, Gullen E, Lee CS, Gumina G, Tsujii E, Cheng YC, Chu CK.
J Med Chem (2000) 43 : 2538 -2546
PubMed 10891113 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 4.64 4.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL184 ACYCLOVIR 4.0 1 4.87
CHEMBL81962 1 4.75
CHEMBL86202 1 4.48
CHEMBL314382 1 4.44
CHEMBL2092771 1 -
CHEMBL312839 1 -
CHEMBL86238 1 -
CHEMBL85923 1 -
CHEMBL87439 1 -
CHEMBL83129 1 -
CHEMBL31634 BRIVUDINE 2.0 1 -
CHEMBL441063 1 -
CHEMBL2364540 1 -
CHEMBL420049 1 -
CHEMBL2364538 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL184 ACYCLOVIR EC50 = 13600.0 nM 4.87
CHEMBL81962 EC50 = 18000.0 nM 4.75
CHEMBL86202 EC50 = 33000.0 nM 4.48
CHEMBL314382 EC50 = 36000.0 nM 4.44
CHEMBL2092771 EC50 > 50000.0 nM -
CHEMBL312839 EC50 > 50000.0 nM -
CHEMBL86238 EC50 > 50000.0 nM -
CHEMBL85923 EC50 > 50000.0 nM -
CHEMBL87439 EC50 > 50000.0 nM -
CHEMBL83129 EC50 > 50000.0 nM -
CHEMBL31634 BRIVUDINE EC50 > 50000.0 nM -
CHEMBL441063 EC50 > 50000.0 nM -
CHEMBL2364540 EC50 > 50000.0 nM -
CHEMBL420049 EC50 > 50000.0 nM -
CHEMBL2364538 EC50 > 50000.0 nM -