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Assay Detail

CHEMBL891974

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against hepatitis C virus replication
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Intermediate

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.
Gunic E, Girardet JL, Ramasamy K, Stoisavljevic-Petkov V, Chow S, Yeh LT, Hamatake RK, Raney A, Hong Z.
Bioorg Med Chem Lett (2007) 17 : 2452 -2455
PubMed 17331721 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 8 7.07 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL234899 1 8.10
CHEMBL233207 1 7.66
CHEMBL397573 1 7.41
CHEMBL392305 1 7.04
CHEMBL234444 1 6.84
CHEMBL234445 1 6.79
CHEMBL392895 1 6.38
CHEMBL234251 1 6.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL234899 EC50 = 8.0 nM 8.10
CHEMBL233207 EC50 = 22.0 nM 7.66
CHEMBL397573 EC50 = 39.0 nM 7.41
CHEMBL392305 EC50 = 92.0 nM 7.04
CHEMBL234444 EC50 = 145.0 nM 6.84
CHEMBL234445 EC50 = 163.0 nM 6.79
CHEMBL392895 EC50 = 414.0 nM 6.38
CHEMBL234251 EC50 = 463.0 nM 6.33