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Assay Detail

CHEMBL895335

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antioxidant activity in rat hepatic microsomal membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Liver
Subcellular Microsome
Confidence 2 — Organism
Curated By Autocuration

Target

Liver microsomes (CHEMBL613694)
Type SUBCELLULAR
Organism Rattus norvegicus

Publication

Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.
Buonsanti MF, Bertinaria M, Stilo AD, Cena C, Fruttero R, Gasco A.
J Med Chem (2007) 50 : 5003 -5011
PubMed 17845020 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.66 4.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL244687 1 4.87
CHEMBL557013 1 4.87
CHEMBL394600 1 4.24
CHEMBL363325 1 -
CHEMBL537445 FENOTEROL HBR 1 -
CHEMBL32800 FENOTEROL 4.0 1 -
CHEMBL395082 1 -
CHEMBL244906 1 -
CHEMBL243266 1 -
CHEMBL244321 1 -
CHEMBL538857 1 -
CHEMBL535398 1 -
CHEMBL540130 1 -
CHEMBL535846 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244687 IC50 = 13500.0 nM 4.87
CHEMBL557013 IC50 = 13500.0 nM 4.87
CHEMBL394600 IC50 = 57000.0 nM 4.24
CHEMBL363325 IC50 = 110000.0 nM -
CHEMBL537445 FENOTEROL HBR IC50 = 215000.0 nM -
CHEMBL32800 FENOTEROL IC50 = 229000.0 nM -
CHEMBL395082 IC50 = 298000.0 nM -
CHEMBL244906 IC50 = 123000.0 nM -
CHEMBL243266 IC50 = 156000.0 nM -
CHEMBL244321 IC50 = 286000.0 nM -
CHEMBL538857 IC50 = 156000.0 nM -
CHEMBL535398 IC50 = 286000.0 nM -
CHEMBL540130 IC50 = 298000.0 nM -
CHEMBL535846 IC50 = 123000.0 nM -