Assay Detail
Binding
CHEMBL901117
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Inhibition of bovine thrombin
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 4.90 | 6.07 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394723 | — | — | 1 | 6.07 |
| CHEMBL239127 | — | — | 1 | 5.30 |
| CHEMBL409191 | — | — | 1 | 5.12 |
| CHEMBL268861 | — | — | 1 | 5.00 |
| CHEMBL240132 | — | — | 1 | 4.79 |
| CHEMBL430087 | — | — | 1 | 4.59 |
| CHEMBL410952 | — | — | 1 | 4.47 |
| CHEMBL397831 | — | — | 1 | 4.39 |
| CHEMBL267455 | — | — | 1 | 4.34 |
| CHEMBL397832 | — | — | 1 | - |
| CHEMBL394724 | — | — | 1 | - |
| CHEMBL412487 | — | — | 1 | - |
| CHEMBL412486 | — | — | 1 | - |
| CHEMBL437180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394723 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL239127 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL409191 | — | Ki | = | 7630.0 | nM | 5.12 |
| CHEMBL268861 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL240132 | — | Ki | = | 16300.0 | nM | 4.79 |
| CHEMBL430087 | — | Ki | = | 25600.0 | nM | 4.59 |
| CHEMBL410952 | — | Ki | = | 33600.0 | nM | 4.47 |
| CHEMBL397831 | — | Ki | = | 40400.0 | nM | 4.39 |
| CHEMBL267455 | — | Ki | = | 45600.0 | nM | 4.34 |
| CHEMBL397832 | — | Ki | > | 2500000.0 | nM | - |
| CHEMBL394724 | — | Ki | = | 826800.0 | nM | - |
| CHEMBL412487 | — | Ki | = | 163600.0 | nM | - |
| CHEMBL412486 | — | Activity | - | — | - | |
| CHEMBL437180 | — | Ki | - | — | - |