Assay Detail
Functional
CHEMBL906564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of virus-induced cytopathic effect in wild type HIV 3a infected MT2 cells after 5 days
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.81 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 7.82 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 6.80 |
| CHEMBL373954 | — | — | 1 | 6.04 |
| CHEMBL229283 | — | — | 1 | 5.89 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.44 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 5.32 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.58 |
| CHEMBL122885 | — | — | 1 | 4.58 |
| CHEMBL229284 | — | — | 1 | - |
| CHEMBL229111 | — | — | 1 | - |
| CHEMBL229987 | — | — | 1 | - |
| CHEMBL444314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL373954 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL229283 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL991 | STAVUDINE | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL122885 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL229284 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL229111 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL229987 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL444314 | — | EC50 | > | 200000.0 | nM | - |