Assay Detail
Functional
CHEMBL910476
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Antiviral activity against HIV1 in MAGI-CCR5 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MAGI-CCR5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.64 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.60 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 7.21 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.46 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.30 |
| CHEMBL2448390 | — | — | 1 | - |
| CHEMBL373589 | — | — | 1 | - |
| CHEMBL218256 | — | — | 1 | - |
| CHEMBL2448391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL991 | STAVUDINE | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL2448390 | — | EC50 | > | 400000.0 | nM | - |
| CHEMBL373589 | — | EC50 | > | 400000.0 | nM | - |
| CHEMBL218256 | — | EC50 | > | 400000.0 | nM | - |
| CHEMBL2448391 | — | EC50 | > | 400000.0 | nM | - |