Assay Detail
Functional
CHEMBL910483
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Antiviral activity against HSV1 KOS in HEL cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.02 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.72 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 7.02 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.32 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | - |
| CHEMBL2448390 | — | — | 1 | - |
| CHEMBL373589 | — | — | 1 | - |
| CHEMBL218256 | — | — | 1 | - |
| CHEMBL2448391 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 300000.0 | nM | - |
| CHEMBL2448390 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL373589 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL218256 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL2448391 | — | EC50 | > | 200000.0 | nM | - |